Extrachromosomal circular DNA is common in yeast | PNAS via exchangle
Extrachromosomal circular DNA is common in yeast | PNAS via exchangle
We performed a screen for extrachromosomal circular DNAs containing segments of genomic yeast DNA. We found 1,756 such extrachromosomal circular DNAs containing about 23% of the total yeast genomic information. The abundance of these circular forms of genomic DNA suggests that eccDNA formation might be a common mutation that can arise in any part of the genome, and not in only a few special loci. We propose that eccDNAs may be precursors to the copy number variation in eukaryotic genomes characteristic of both the evolutionary process and cancer progression.
Source:
www.exchangle.com
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