RedGage

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Madrid, Spain.Phone: +34 Email: andermayor@gmail.com Summary of the articles main points:• Zinc deficiency might be common in severe infection• Low levels of Zinc have been correlated with higher IL-6 responses • IL-6 plays an important role on lung severe injury from COVID-19 infection.• Zinc inhibits SARS-COV RNA polymerase, inhibiting its replication capacity.• Zinc might increase antimalarials efficacy, since they act as a zinc iontophore.• Differences in mortality caused by COVID-19 infection, might be explained in some degree, by -17C IL-6 gene polymorphism.No funding was received in order of making this manuscript.Zinc is an essential element of our organism. Its link to the proper functioning of the immune system is historical. This manuscript summarizes the main mechanisms that link it to COVID-19 infection. We hypothesize that a deficiency of it may be relevant to the development of a severe infection. We also hypothesize that a polymorphism in the IL-6 gene may explain the difference in mortality between countries. We suggest that zinc supplementation may enhance the action of antimalarials to treat this infection.Zinc is the second most abundant trace metal in the human body after iron, however, unlike iron, there is no specialized zinc store (1). Zinc deficiency can precipitate an immune system imbalance, exemplified in severe deficiency by a high susceptibility to infections, severe dermatological manifestations, gastrointestinal disturbances, weight loss, gr...