Single-molecule visualization of DNA G-quadruplex formation in live cells getmixapp
Single-molecule visualization of DNA G-quadruplex formation in live cells getmixapp
Visualization of endogenous G-quadruplexes (G4s) in living cells by fluorescence microscopy has been hampered by the high concentrations of G4-binding probes required, which can artificially induce additional G4 formation. Now, a G4-specific fluorescent probe (SiR-PyPDS) has been developed that enables single-molecule and real-time detection of individual G4 structures in living cells without perturbing G4 formation and dynamics.
Source:
mix.com
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