Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection getmixapp
Identification of existing pharmaceuticals and herbal medicines as inhibitors of SARS-CoV-2 infection getmixapp
COVID-19 is a global pandemic currently lacking an effective cure. We used a cell-based infection assay to screen more than 3,000 agents used in humans and animals and identified 15 with antiinfective activity, ranging from 0.1 nM to 50 μM. We then used in vitro enzymatic assays combined with computer modeling to confirm the activity of those against the viral protease and RNA polymerase. In...
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