The enemy within: endogenous retroelements and autoimmune disease via exchangle
The enemy within: endogenous retroelements and autoimmune disease via exchangle
Inappropriate or chronic detection of self nucleic acids by the innate immune system underlies many human autoimmune diseases. We discuss here an unexpected source of endogenous immunostimulatory nucleic acids: the reverse-transcribed cDNA of endogenous retroelements. The interplay between innate im
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